BENGALURU, India — Sizzling heat across Asia and the Middle East in late April that echoed last year’s destructive swelter was made 45 times more likely in some parts of the continent because of human-caused climate change, a study Tuesday found. 

Scorching temperatures were felt across large swaths of Asia, from Gaza in the west — where over 2 million people face clean water shortages, lack of health care and other essentials amid the Israeli bombardment — to the Philippines in the southeast, with many parts of the continent experiencing temperatures well above 40 degrees Celsius (104 degrees Fahrenheit) several days in a row. 

The study was released by the World Weather Attribution group of scientists, who use established climate models to quickly determine whether human-caused climate change played a part in extreme weather events around the world. 

In the Philippines, scientists found the heat was so extreme it would have been impossible without human-caused climate change. In parts of the Middle East, climate change increased the probability of the event by about a factor of five. 

“People suffered and died when April temperatures soared in Asia,” said Friederike Otto, study author and climate scientist at Imperial College in London. “If humans continue to burn fossil fuels, the climate will continue to warm, and vulnerable people will continue to die.” 

At least 28 heat-related deaths were reported in Bangladesh, as well as five in India and three in Gaza in April. Surges in heat deaths have also been reported in Thailand and the Philippines this year according to the study. 

The heat also had a large impact on agriculture, causing crop damage and reduced yields, as well as on education, with school vacations having to be extended and schools closed in several countries, affecting thousands of students. 

Myanmar, Laos and Vietnam broke records for their hottest April day, and the Philippines experienced its hottest night ever with a low of 29.8 degrees Celsius (85.6 degrees Fahrenheit). In India, temperatures reached as high as 46 degrees Celsius (115 degrees Fahrenheit). The month was the hottest April on record globally and the 11th consecutive month that broke the hottest-month record. 

Climate experts say extreme heat in South Asia during the pre-monsoon season is becoming more frequent and the study found that extreme temperatures are now about 0.85 degrees Celsius (1.5 Fahrenheit) hotter in the region because of climate change. 

Internally displaced people, migrants and those in refugee camps were especially vulnerable to the searing temperatures, the study found. 

“These findings in scientific terms are alarming,” said Aditya Valiathan Pillai, a heat plans expert at New Delhi-based think tank Sustainable Futures Collaborative. “But for people on the ground living in precarious conditions, it could be absolutely deadly.” Pillai was not part of the study. 

Pillai said more awareness about heat risks, public and private investments to deal with increasing heat, and more research on its impacts are all necessary to deal with future heat waves. 

“I think heat is now among the foremost risks in terms of personal health for millions across the world as well as nations’ economic development,” he said. 
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mbale, uganda — Barbara Nabulo was one of three girls in her family. But when a sister died, her mother wailed at the funeral that she was left with just one and a half daughters.

The half was the ailing Nabulo, who at age 12 understood her mother’s meaning.

“I hated myself so much,” Nabulo said recently, recalling the words that preceded a period of sickness that left her hospitalized and feeding through a tube.

The scene underscores the lifelong challenges for some people with sickle cell disease in rural Uganda, where it remains poorly understood. Despite Nabulo’s knowledge of how the disease weakens the body, she spoke repeatedly of “the germ I was born with.”

Infections, pain, organ damage

Sickle cell disease is a group of inherited disorders in which red blood cells — normally round — become hard, sticky and crescent shaped. The misshapen cells clog the flow of blood, which can lead to infections, excruciating pain, organ damage and other complications.

The disease, which can stunt physical growth, is more common in malaria-prone regions, notably Africa and India, because carrying the sickle cell trait helps protect against severe malaria. Global estimates of how many people have the disease vary, but some researchers put the number between 6 million and 8 million, with more than 5 million living in sub-Saharan Africa.

The only cure for the pain sickle cell disease can cause is a bone marrow transplant or gene therapies such as the one commercially approved by the U.S. Food and Drug Administration in December. Last week, a 12-year-old boy last week became the first person to begin the therapy.

Those options are beyond the reach of most patients in this East African nation, where sickle cell disease is not a public health priority despite the burden it places on communities. There isn’t a national database of sickle cell patients. Funding for treatment often comes from donor organizations.

A patient, a caregiver

In a hilly part of eastern Uganda that’s a sickle cell hot spot, the main referral hospital looks after hundreds of patients arriving from nearby villages to collect medication. Many receive doses of hydroxyurea, a drug that can reduce periods of severe pain and other complications, and researchers there are studying its effectiveness in Ugandan children.

Nabulo, now 37, is one of the hospital’s patients. But she approaches others like her as a caregiver, too.

After dropping out in primary school, she has emerged in recent years as a counselor to fellow patients, speaking to them about her survival. Encouraged by hospital authorities, she makes weekly visits to the ward that has many children watched over by exhausted-looking parents.

Nabulo tells them she was diagnosed with sickle cell disease at 2 weeks old, but now she is the mother of three children, including twins.

Such a message gives hope to those who feel discouraged or worry that sickle cell disease is a death sentence, said Dr. Julian Abeso, head of pediatrics at Mbale Regional Referral Hospital.

Some men have been known to divorce their wives — or neglect them in search of new partners — when they learn that their children have sickle cell disease. Frequent community deaths from disease complications reinforce perceptions of it as a scourge.

Health workers encourage testing

Nabulo and health workers urge openness and the testing of children for sickle cell as early as possible.

Abeso and Nabulo grew close after Nabulo lost her first baby hours after childbirth in 2015. She cried in the doctor’s office as she spoke of her wish “to have a relative I can call mine, a descendant who can help me,” Abeso recalled.

“At that time, people here were so negative about patients with sickle cell disease having children because the complications would be so many,” the doctor said.

Nabulo’s second attempt to have a child was difficult, with some time in intensive care. But her baby is now a 7-year-old boy who sometimes accompanies her to the hospital. The twin girls came last year.

Speaking outside the one-room home she shares with her husband and children, Nabulo said many people appreciate her work despite the countless indignities she faces, including unwanted stares from people in the streets who point to the woman with “a big head” — a manifestation of the disease in her. Her brothers often behave as if they are ashamed of her, she said.

Once, she heard of a girl in her neighborhood whose grandmother was making frequent trips to the clinic over an undiagnosed illness in the child. The grandmother was hesitant to have the girl tested for sickle cell when Nabulo first asked her. But tests later revealed the disease, and now the girl receives treatment.

“I go to Nabulo for help because I can’t manage the illness affecting my grandchild,” Kelemesiya Musuya said. “She can feel pain, and she starts crying, saying, ‘It is here and it is rising and it is paining here and here.'”

Musuya sometimes seeks reassurance. “She would be asking me, ‘Even you, when you are sick, does it hurt in the legs, in the chest, in the head?’ I tell her that, yes, it’s painful like that,” Nabulo said.

Nabulo said she was glad that the girl, who is 11, still goes to school.

The lack of formal education is hurtful for Nabulo, who struggles to write her name, and a source of shame for her parents, who repeatedly apologize for letting her drop out while her siblings studied. One brother is now a medical worker who operates a clinic in a town not far away from Nabulo’s home.

“I am very happy to see her,” said her mother, Agatha Nambuya.

She recalled Nabulo’s swelling head and limbs as a baby, and how “these children used to die so soon.”

But now she knows of others with sickle cell disease who grew to become doctors or whatever they wanted to be. She expressed pride in Nabulo’s work as a counselor and said her grandchildren make her feel happy.

“At that time,” she said, recalling Nabulo as a child, “we didn’t know.”
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BEIJING — Cases of bird flu have been confirmed among wild fowl in western China, the agriculture ministry said Saturday, as concerns grow over a U.S. outbreak infecting cattle. 

Two counties in Qinghai province confirmed 275 cases of H5 influenza among dead Pallas’s gull and other wild birds, China’s Ministry of Agriculture and Rural Affairs said in a notice on its website. 

The ministry received a report on the cases from the China Animal Disease Control Center, and the national Avian Influenza Reference Laboratory confirmed the finding, the notice said. 

The H5N1 outbreak among dairy cattle in at least nine U.S. states since late March has raised questions over whether it could spread to humans. No such cases have been reported. 

The U.S. announced on May 11 that it would spend close to $200 million to fight the outbreak. 

News of the China bird flu cases came as the nation’s anti-graft watchdog announced a corruption probe of the agriculture minister Saturday. 

Tang Renjian, 61, is under investigation for “serious violations of discipline and law” by the Central Commission for Discipline Inspection and National Supervisory Commission, CCDI said on its website. 

The term is CCDI’s typical euphemism for corruption. 

The notice gave no further details. 
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NEW DELHI — Parts of northwest India sweltered under scorching temperatures Saturday, with the capital, New Delhi, under a severe weather alert as extreme temperatures struck parts of the country.

India’s weather department expects heat wave conditions to persist across the north for the next few days and has put several states on high alert.

On Friday, parts of New Delhi reported up to 47.1 degrees Celsius (116 Fahrenheit). The nearby states of Punjab, Haryana and Rajasthan also saw temperatures soar; they are likely to stay high over the next few days, said Soma Sen Roy, a scientist at the India Meteorological Department.

Roy cautioned people against going outdoors under the afternoon sun. He advised drinking plenty of water and wearing loose-fitting clothes. Those who are especially vulnerable, such as the elderly, should stay indoors, he said.

The extreme temperatures coincide with a six-week-long general election, with experts worried that the heat wave could increase health risks as people wait in long lines to cast their vote or candidates campaign aggressively in the outdoors. One minister fainted due to heat last month while addressing an election rally in Maharashtra state.

Prime Minister Narendra Modi and his main challenger, Rahul Gandhi of the opposition Congress Party, were expected to hold rallies in New Delhi later Saturday, as the city heads to the polls on May 25.

Satish Kumar, a 57-year-old rickshaw driver in the capital, said his work was suffering because of the heat. “People are not coming outside, [markets] are nearly empty,” he said.

Pravin Kamath, a 28-year-old who runs a cart selling cold drinks, complained that it was so hot he could hardly stand being outdoors. “But I must work. What can I do? I am poor, so I have to do it.”

The main summer months — April, May and June — are always hot in most parts of India before monsoon rains bring cooler temperatures. But the heat has become more intense in the past decade and is usually accompanied by severe water shortages, with tens of millions of India’s 1.4 billion people lacking running water.

A study by World Weather Attribution, an academic group that examines the source of extreme heat, found that a searing heat wave in April that struck parts of Asia was made at least 45 times more likely in some parts of the continent by climate change.

Climate experts say extreme heat in South Asia during the pre-monsoon season is becoming more frequent and the study found that extreme temperatures are now about 0.85 C (1.5 F) hotter in the region because of climate change.

At least 28 heat-related deaths were reported in Bangladesh, as well as five in India, in April. Surges in heat deaths have also been reported in Thailand and the Philippines this year, according to the study.

Extreme heat is fast becoming a public health crisis in India, with more than 150 people dying last year during heat waves. The government estimates nearly 11,000 people have died during heat waves this century, yet experts say such figures are likely a vast undercount.
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LONDON — A scenic fishing village in southwestern England was under instructions to boil its tap water for a third day on Friday after a parasite sickened more than 45 people in the latest example of Britain’s troubled water system.

Around 16,000 homes and businesses in the Brixham area of Devon were told to boil water after cryptosporidium, a microscopic parasite that causes diarrhea, was found in the water. At least 46 cases of cryptosporidiosis have been confirmed and more than 100 other people have reported similar symptoms, the U.K. Health Security Agency said. Symptoms can last more than two weeks.

Sally Dart, who runs a housewares shop near Brixham Harbor, said people in town first began feeling ill two weeks ago during a pirate festival.

“No one was checking the quality of the water, and we’ve all got sick and it’s stupid,” she said. 

South West Water’s Chief Executive Susan Davy apologized for the outbreak and said technicians were working around the clock to identify and fix the problem that may have come from a pipe in a cattle pasture.

“I am truly sorry for the disruption and wider anxiety this has caused,” Davy said. “I know on this occasion we have fallen significantly short of what you expect of us.”

The crisis is unrelated to Britain’s larger ongoing water woes but emblematic of an aging system in distress.

Water companies have been under fire for more than a year to stop frequent sewage overflows into rivers and oceans that have literally caused a stink, sickened swimmers, polluted fishing streams and led to an outcry from the public to clean up their act.

An environmental group this week reported that 70,000 sewage releases spilled for a total of 400,000 hours along England’s coast last year. More than a quarter were within 3.2 kilometers of a swimming spot, Friends of the Earth said in its analysis of government data.

Clean water advocates have blamed the problems on Britain’s privatization of the water system in 1989. They say that companies have put shareholders ahead of customers and not spent enough to update outdated plumbing systems.

Thames Water, the largest of the companies, is on the brink of insolvency and its leaders have said it faces the risk of being nationalized after shareholders refused to inject more cash.

Earlier this week, in another sign of problems, millions of gallons of raw sewage were pumped into England’s largest lake. After a fault caused pumps to fail, backup systems then pumped human waste into Lake Windermere, a UNESCO World Heritage site, for 10 hours, the BBC reported.

The cryptosporidiosis outbreak is hardly the first time South West Water has encountered problems, according to authorities.

The company is facing charges in Plymouth Magistrates’ Court alleging 30 offenses for illegal water discharges or breaches of environmental permits between 2015 and 2021, the Environment Agency said.

The recent outbreak appears to come from a damaged air valve in a pipe that runs through a field where cows graze that is close to a reservoir, said Laura Flowerdew, a spokesperson for South West.

With word out about the outbreak, Dart said her business is down by about a third and other merchants complained about a loss of income as warmer weather arrives and a holiday weekend is just a week away.

“I would say it’s quiet and it shouldn’t be at this time of year,” Dart said.

A primary school was forced to close Thursday because it didn’t have clean drinking water. The water company is providing free bottled water at three locations and has increased compensation to customers from 15 pounds ($19) to 115 ($145).

Paul Hunter, a professor in medicine at the University of East Anglia, said it’s likely more people will become ill with cryptosporidiosis in coming days or weeks because of a lag in the incubation period.

“Even if they have stopped all new infections by now, you would expect to see further cases for at least 10 days to two weeks,” he told the BBC.

Anthony Mangnall, a Conservative member of Parliament from the area, said residents are likely to have to boil water for another week. He said he was concerned with the water company’s response to the outbreak and vowed to hold it accountable.

“They have been slow to act and communication with customers has been very poor,” Mangnall said. “This has certainly undermined trust in our water network.”
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The effects of recent extreme weather in Southeast Asian countries are far-reaching, from school closures to drought and health advisories. While climate change is part of the problem, this year it was made worse by the cyclical weather pattern called El Nino. VOA’s Chris Casquejo explains.
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SYDNEY — Australian scientists say they have discovered how an enzyme “hidden in nature’s blueprint” could help develop climate-resilient crops able to remove more carbon dioxide from the atmosphere. 

An Australian study, by researchers from Australian National University and the University of Newcastle in New South Wales, focuses on a type of bacteria researchers call “tiny carbon superheroes.” 

Cyanobacteria, a type of algae-like bacteria also called blue-green algae, are found in fresh and coastal waters, as well as oceans.  They are commonly known for their toxic blooms in lakes and rivers.  

Through the process of photosynthesis, Australian scientists say, they capture about 12% of the world’s carbon dioxide each year. 

Their study says a carbon dioxide-concentrating mechanism in cyanobacteria lets them turn atmospheric carbon dioxide into sugars for cells to eat more quickly than most standard plants and crops.

Until now, the Australian team was unaware how critical an enzyme in cyanobacteria, called carboxysomal carbonic anhydrase, was to the process. The study says the mystery of how the enzyme maximizes the cyanobacteria’s ability to extract atmospheric carbon dioxide has been solved.

Ben Long, a senior lecturer in molecular plant biology at Australia’s University of Newcastle and is the study’s lead author.

He told VOA that the aim is to engineer crops that can absorb more greenhouse gases.   

“We are actually interested in utilizing this CO2-concentrating mechanism from cyanobacteria, which we know is a remarkably efficiently system for capturing CO2 and we want to engineer that into plant cells to make plant cells able to capture CO2 far more effectively and efficiently,” Long said.

The research says that engineered plants that are more efficient at capturing carbon dioxide could increase crop yield, making global food systems that are more resilient to climate change. 

Long says the findings should be part of international efforts to reduce greenhouse gases.  

“Every technology has to be brought to bear to try to reduce CO2 emissions and reduce CO2 in the atmosphere and I think to date we have not really focused much on those potential biological applications to reduce greenhouse gas emissions,” Long said.

The study has been published in the journal Science Advances.
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CAPE CANAVERAL, FLORIDA — The Webb Space Telescope has discovered the earliest known merger of black holes.

These two gigantic black holes and their galaxies consolidated just 740 million years after the universe-forming Big Bang. It’s the most distant detection ever made of merging black holes, scientists reported Thursday.

One black hole is 50 million times more massive than our sun. The other is thought to be similar in size, but is buried in dense gas, which makes it harder to measure.

Until now, astronomers weren’t sure how supermassive black holes got so big.

The latest findings, published in the Monthly Notices of the Royal Astronomical Society, suggest mergers are how black holes can grow so rapidly — “even at cosmic dawn,” said lead author Hannah Ubler of the University of Cambridge.

“Massive black holes have been shaping the evolution of galaxies from the very beginning,” Ubler said in a statement.

Launched in 2021 as the eventual successor to NASA’s Hubble Space Telescope, Webb is the biggest and most powerful observatory ever sent into space. A joint U.S.-European project, the infrared observatory surveys the universe from a location 1.6 million kilometers from Earth.
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NEW YORK — The number of fatal overdoses in the U.S. fell last year, according to Centers for Disease Control and Prevention data posted Wednesday.

Agency officials noted that the data is provisional and could change after more analysis, and that they still expect a drop when the final counts are in. It would be only the second annual decline since the current national drug death epidemic began more than three decades ago.

Experts reacted cautiously. One described the decline as relatively small and said it should be thought of as part of a leveling off rather than a decrease. Another noted that the last time a decline occurred — in 2018 — drug deaths shot up in the years that followed.

“Any decline is encouraging,” said Brandon Marshall, a Brown University researcher who studies overdose trends. “But I think it’s certainly premature to celebrate or to draw any large-scale conclusions about where we may be headed long term with this crisis.”

It’s also too soon to know what spurred the decline, Marshall and other experts said. Explanations could include shifts in the drug supply, expansion of overdose prevention and addiction treatment, and the grim possibility that the epidemic has killed so many that now there are basically fewer people to kill.

CDC Chief Medical Officer Dr. Debra Houry called the dip “heartening news” and praised efforts to reduce the tally, but she noted that “there are still families and friends losing their loved ones to drug overdoses at staggering numbers.”

About 107,500 people died of overdoses in the U.S. last year, including American citizens and noncitizens who were in the country at the time they died, the CDC estimated. That’s down 3% from 2022, when there were an estimated 111,000 such deaths, the agency said.

The drug overdose epidemic, which has killed more than 1 million people since 1999, has had many ripple effects. For example, a study published last week in JAMA Psychiatry estimated that more than 321,000 U.S. children lost a parent to a fatal drug overdose from 2011 to 2021.

“These children need support” and are at a higher risk of mental health and drug use disorders themselves, said Dr. Nora Volkow, director of the National Institute on Drug Abuse, which helped lead the study. “It’s not just a loss of a person. It’s also the implications that loss has for the family left behind.”

Prescription painkillers once drove the nation’s overdose epidemic, but they were supplanted years ago by heroin and more recently by illegal fentanyl. The dangerously powerful opioid was developed to treat intense pain from ailments such as cancer but has increasingly been mixed with other drugs in the illicit drug supply.

For years, fentanyl was frequently injected, but increasingly it’s being smoked or mixed into counterfeit pills.

A study published last week found that law enforcement seizures of pills containing fentanyl are rising dramatically, jumping from 44 million in 2022 to more than 115 million last year.

It’s possible that the seizures indicate that the overall supply of fentanyl-laced pills is growing fast, not necessarily that police are whittling down the illicit drug supply, said one of the paper’s authors, Dr. Daniel Ciccarone of the University of California, San Francisco.

He noted that the decline in overdoses was not uniform. All but two of the states in the eastern half of the U.S. saw declines, but most Western states saw increases. Alaska, Washington and Oregon each saw 27% increases.

The reason? Many Eastern states have been dealing with fentanyl for about a decade, while it’s reached Western states more recently, Ciccarone said.

Nevertheless, some researchers say there are reasons to be optimistic. It’s possible that smoking fentanyl is not as lethal as injecting it, but scientists are still exploring that question.

Meanwhile, more money is becoming available to treat addiction and prevent overdoses, through government funding and legal settlements with drugmakers, wholesalers and pharmacies, Ciccarone noted.

“My hope is 2023 is the beginning of a turning point,” he said. 
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A groundbreaking clinical trial is underway in South Africa, marking a pivotal moment in the fight against tuberculosis. The new vaccine could become the first to help prevent pulmonary TB, the most common form of the disease, in adolescents and adults. It would be the first new TB vaccine in more than a century. Zaheer Cassim has the story.
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Washington — The spectacular auroras that danced across the sky in many parts of the world over the weekend are fading, scientists said Monday, as the massive sunspot that caused them turns its ferocious gaze away from Earth.

Since Friday, the most powerful solar storm to strike our planet in more than two decades has lit up night skies with dazzling auroras in the United States, Tasmania, the Bahamas and other places far from the extreme latitudes where they are normally seen.

But Eric Lagadec, an astrophysicist at France’s Observatoire de la Cote d’Azur, told AFP that the “most spectacular” period of this rare event has come to an end.

The first of several coronal mass ejections (CMEs) — expulsions of plasma and magnetic fields from the Sun — came just after 1600 GMT Friday, according to the US-based National Oceanic and Atmospheric Administration (NOAA).

The event was later upgraded to an “extreme” geomagnetic storm — the first since the “Halloween Storms” of October 2003 that caused blackouts in Sweden and damaged power infrastructure in South Africa.

Excitement over the phenomenon — and otherworldly photos of pink, green and purple night skies — broke out across the world, from Austria to Australia’s island state of Tasmania.

The storm had been forecast to intensify again until 0600 GMT Monday, the NOAA said, adding that auroras could be viewable as far south as New York.

But thousands of people who came out on Sunday night in the hope of seeing the aurora borealis over the Joshua Tree National Park in California instead saw the Milky Way. AFP pictures showed stars shining clearly in the night sky.

Lagadec said that while there were further solar outbursts on Sunday, it is unlikely that more auroras will be visible to the naked eye in lower latitudes such as in France.

“Only the most experienced photographers will be able to capture them” in such areas, said Lagadec, who was moved by witnessing an aurora during the event’s peak on Friday night.

The solar storm emanated from a massive sunspot cluster that is 17 times wider than our planet.

The storm has not ended, and auroras are expected to continue in the far northern or southern regions where they are normally visible.

But “the source of the storm is a sunspot that is now on the edge of the Sun, (so) we do not expect the next coronal mass ejections to head in Earth’s direction,” Lagadec said.

Scientists had already warned that the intensity of anything seen on Sunday night would unlikely reach the level of Friday’s show.

“This is likely the last of the Earth-directed CMEs from this particular monster sunspot,” Mathew Owens, a professor of space physics at the UK’s University of Reading, told AFP.

When charged particles from solar winds are captured by Earth’s magnetic field, they accelerate towards the planet’s magnetic poles, which is why auroras are normally seen there.

But during periods of heightened solar activity, the effects extend farther toward the equator.

Unlike during 2003’s solar storms, no major disruptions to power or communications networks appear to have been reported this time around.

Elon Musk’s satellite internet operator Starlink said on X that its thousands of satellites in low Earth orbit had “weathered the geomagnetic storm and remain healthy”.

Unlike solar flares, which travel at the speed of light and reach Earth in around eight minutes, CMEs travel at a more sedate pace, with officials putting the current average at 800 kilometers (500 miles) per second.

People with eclipse glasses can still look for the sunspot cluster during the day.

Fluctuating magnetic fields associated with geomagnetic storms induce currents in long wires, including power lines, which can lead to blackouts. Long pipelines can also become electrified.

Spacecraft are at risk from high doses of radiation, although the atmosphere prevents this from reaching Earth.

NASA can ask astronauts on the International Space Station to move to better-shielded places within the outpost.

Even pigeons and other species that have internal biological compasses can be affected.
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Washington — The first living patient to receive a genetically modified pig kidney transplant has died two months after the procedure, the US hospital that carried it out said.

“Mass General is deeply saddened at the sudden passing of Mr. Rick Slayman. We have no indication that it was the result of his recent transplant,” the Boston hospital said in a statement issued late Saturday.

In a world first, surgeons at Massachusetts General Hospital in March successfully transplanted the genetically edited pig kidney into Slayman, who was 62 years old at the time and suffering from end-stage kidney disease.

“Slayman will forever be seen as a beacon of hope to countless transplant patients worldwide and we are deeply grateful for his trust and willingness to advance the field of xenotransplantation,” the hospital statement said.

Organ shortages are a chronic problem around the world and Mass General said in March that there were more than 1,400 patients on its waiting list for a kidney transplant.

The pig kidney used for the transplant was provided by a Massachusetts biotech company called eGenesis and had been modified to remove harmful pig genes and add certain human genes, according to the hospital.

Slayman, who suffered from Type 2 diabetes and hypertension, had received a transplanted human kidney in 2018, but it began to fail five years later.

When the hospital announced the successful transplant in March, Slayman said he had agreed to the procedure “not only as a way to help (him), but a way to provide hope for the thousands of people who need a transplant to survive.”

In a statement posted on Mass General’s website, his family said while they were “deeply saddened about the sudden passing of our beloved Rick” they took “great comfort knowing he inspired so many.”

The family said they were “comforted by the optimism he provided patients desperately waiting for a transplant”.

More than 89,000 patients were on the national kidney waiting list as of March this year, according to a US health department website.

On average, 17 people die each day while waiting for an organ transplant.

Slayman’s family also thanked the doctors “who truly did everything they could to help give Rick a second chance. Their enormous efforts leading the xenotransplant gave our family seven more weeks with Rick, and our memories made during that time will remain in our minds and hearts.”

“After his transplant, Rick said that one of the reasons he underwent this procedure was to provide hope for the thousands of people who need a transplant to survive,” the family added.

“His legacy will be one that inspires patients, researchers, and health care professionals.”

The transplantation of organs from one species to another is a growing field known as xenotransplantation.

About a month after Slayman’s procedure, surgeons at NYU Langone Health in New York carried out a similar transplant on Lisa Pisano, who had suffered heart failure and end-stage kidney disease.

Pig kidneys had been transplanted previously into brain-dead patients, but Slayman was the first living person to receive one.

Genetically modified pig hearts were transplanted in 2023 into two patients at the University of Maryland, but both lived less than two months.

Mass General said Slayman’s transplant had been carried out under a policy known as “compassionate use” that allows patients with “serious or life-threatening conditions” to access experimental therapies not yet approved by the US Food and Drug Administration.
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New York — All dogs coming into the U.S. from other countries must be at least 6 months old and microchipped to help prevent the spread of rabies, according to new government rules published Wednesday.

The new rules require vaccination for dogs that have been in countries where rabies is common. The update applies to dogs brought in by breeders or rescue groups as well as pets traveling with their U.S. owners.

“This new regulation is going to address the current challenges that we’re facing,” said Emily Pieracci, a rabies expert at the Centers for Disease Control and Prevention who was involved in drafting the updated regulations.

The CDC posted the new rules in the federal register on Wednesday. They take effect Aug. 1 when a temporary 2021 order expires. That order suspended bringing in dogs from more than 100 countries where rabies is still a problem.

The new rules require all dogs entering the U.S. to be at least 6 months, old enough to be vaccinated if required, and for the shots to take effect; have a microchip placed under their skin with a code that can be used to verify rabies vaccination; and have completed a new CDC import form.

There may be additional restrictions and requirements based on where the dog was the previous six months, which may include blood testing from CDC-approved labs.

The CDC regulations were last updated in 1956, and a lot has changed, Pieracci said. More people travel internationally with their pets, and more rescue groups and breeders have set up overseas operations to meet the demand for pets, she said. Now, about 1 million dogs enter the U.S. each year.

Dogs were once common carriers of the rabies virus in the U.S. but the type that normally circulates in dogs was eliminated through vaccinations in the 1970s. The virus invades the central nervous system and is usually a fatal disease in animals and humans. It’s most commonly spread through a bite from an infected animal. There is no cure for it once symptoms begin.

Four rabid dogs have been identified entering the U.S. since 2015, and officials worried more might get through. CDC officials also were seeing an increase of incomplete or fraudulent rabies vaccination certificates and more puppies denied entry because they weren’t old enough to be fully vaccinated.

A draft version of the updated regulations last year drew a range of public comments.

Angela Passman, owner of a Dallas company that helps people move their pets internationally, supports the new rules. It can especially tricky for families that buy or adopt a dog while overseas and then try to bring it to the U.S., she said. The update means little change from how things have been handled in recent years, she said.

“It’s more work for the pet owner, but the end result is a good thing,” said Passman, who is a board member for the International Pet and Animal Transportation Association.

But Jennifer Skiff said some of the changes are unwarranted and too costly. She works for Animal Wellness Action, a Washington group focused on preventing animal cruelty that helps organizations import animals.

She said those groups work with diplomats and military personnel who have had trouble meeting requirements, and was a reason some owners were forced to leave their dogs behind.
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ALBUQUERQUE, New Mexico — The U.S. government is dedicating $60 million over the next few years to projects along the Rio Grande in southern New Mexico and West Texas to make the river more resilient in the face of climate change and growing demands.

The funding announced Friday by U.S. Interior Secretary Deb Haaland marks the first disbursement from the Inflation Reduction Act for a basin outside of the Colorado River system. While pressures on the Colorado River have dominated headlines, Haaland and others acknowledged that other communities in the West — from Native American reservations to growing cities and agricultural strongholds — are experiencing the effects of unprecedented drought.

Water users and managers can’t afford to waste one drop, Haaland said, sharing the advice her own grandmother used to give when she and her cousins would carry buckets of water to their home at Laguna Pueblo for cooking, cleaning and bathing.

“She was teaching us how precious water is in the desert,” Haaland said, standing among the cottonwoods that make up a green belt that stretches the length of the river from the Colorado-New Mexico border south into Texas and Mexico.

Haaland noted that parts of the river have gone dry through the Albuquerque stretch in recent years. In fact, a decades-long drought has led to record low water levels throughout the Rio Grande Basin.

“When drought conditions like this strike, we know it doesn’t just impact one community, it affects all of us,” she said, pointing to the importance of investing in water projects throughout the basin.

One of the longest rivers in North America, the Rio Grande provides drinking water for millions of people and supplies thousands of farmers with water for crops. Management of the river has sparked legal battles over the decades, with the most recent case pending before the U.S. Supreme Court as New Mexico, Texas and Colorado seek approval of a settlement that will help ensure they have more flexibility in the future.

U.S. Rep. Melanie Stansbury, a New Mexico Democrat, said improving sustainability along the Rio Grande will help the state meets obligations under a decades-old compact to deliver water downstream to Texas and ultimately Mexico.

Irrigation districts in southern New Mexico and El Paso, Texas, will work with the New Mexico Interstate Stream Commission, the National Fish and Wildlife Foundation and the U.S. Bureau of Reclamation to develop projects that will benefit the river and endangered species that inhabit the basin.

The work will range from capturing more stormwater runoff to improving existing infrastructure. Officials said the savings could result in tens of thousands of acre-feet of water. An acre-foot is roughly enough to serve two to three U.S. households annually.

In all, the Inflation Reduction Act provides $4 billion for mitigating drought in 17 western states, with the priority being the Colorado River Basin. However, the legislation also carved out $500 million for water management and conservation projects in other basins that are experiencing similar levels of long-term drought.

The U.S. Bureau of Reclamation said funding for other basins will be announced later this year, with the goal of putting the money to use over the next four years.

On the Rio Grande, prolonged drought and heavy reliance on groundwater pumping has reduced surface water supplies, resulting in decreased efficiency and lost wildlife habitat.

By capturing more stormwater and increasing storage, officials said they could recharge aquifers and reduce irrigation demands.

Some of that work already is happening in the Elephant Butte Irrigation District, which serves about 5,000 farmers in southern New Mexico. Near the farming village of Rincon, officials are working to slow down runoff and keep sediment from clogging channels that feed the river.

It’s among several projects that the irrigation district has proposed to federal officials to save water, protect communities from seasonal flooding and restore habitat.

Irrigation district manager Gary Esslinger and Samantha Barncastle, a water attorney who represents the district, traveled to Albuquerque on Friday to participate in a briefing with Haaland and other officials. They described the efforts as “re-plumbing” the West with irrigation and flood control systems that can accommodate the changing conditions.

“It’s quite a large vision,” Barncastle said, “but it’s what everyone should be doing — thinking big is the only way to resolve the climate crisis.”
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SANFORD, Florida — With the start of hurricane season less than a month away, U.S. officials who predict, prepare for and respond to natural disasters had a message for Floridians on Friday: It’s not a matter of if a hurricane will hit, but when.

The 2024 hurricane season is expected to be busier than average. To ensure that people everywhere are prepared, officials visited residents in Sanford, a landlocked city in the middle of the Sunshine State.

Even if they don’t live on the coast, the officials told residents, they need to know the potential danger hurricanes pose to their property, such as flooding; and put together an emergency plan that includes a supply kit.

“Everybody in Florida is at risk,” said Michael Brennan, director of the National Hurricane Center.

As if to punctuate Florida’s vulnerability to damaging weather, wind gusts of 114 kph, just shy of hurricane force, were recorded early Friday in Tallahassee, where mangled metal and other debris from damaged buildings littered parts of the state’s capital city.

The officials in Sanford brought along two “hurricane hunter” planes used in the daredevil business of flying into the middle of storms to gather data about their intensity and direction.

The WP-3D, operated by the National Oceanic and Atmospheric Administration, and the WC-130J, flown by the U.S. Air Force Reserve, fly straight into the storms’ eyewall, usually three times during a flight. The aim of the hair-raising trips is to gather information that can help officials on the ground make decisions such as when to order people to evacuate.

NOAA’s propeller plane typically has 11-17 people on board during flights through hurricanes, including the crew and scientists. Since flights usually last eight hours, the crew members bring plenty of snack food, and there is a microwave, refrigerator and a hot plate for cooking more elaborate meals.

Although the rides can be very bumpy, sometimes they aren’t as turbulent as expected and crew members don’t realize that they already are in the eye of a hurricane, said William Wysinger, a NOAA flight engineer who has flown on a dozen missions through hurricanes.

“I liken it to riding an old wooden roller coaster during the worst of times,” Wysinger said.

The National Hurricane Center is predicting that the upcoming Atlantic and Gulf season, which runs from June 1 to November 30, will exceed the yearly average of seven tropical storms and seven hurricanes, and that three of the storms will be major. Not all hurricanes make landfall.

Floridians would be wise to remember 20 years ago when four hurricanes made landfall consecutively in just a matter of weeks, crisscrossing the state and carving paths of disaster, said David Sharp, meteorologist-in-charge at the National Weather Service in Melbourne, Florida.

“Many remember the ravages of the Hurricanes Charley, Frances, Ivan and Jeanne — blue tarps and pink insulation everywhere, along with displaced lives,” Sharp said. “Scars upon the land but also scars upon the psyche of our people.”

Hundreds of thousands of new residents have arrived in Florida since the last hurricane season, and it’s important that they know what to expect and how to prepare, said Robbie Berg, warning coordination meteorologist at the National Hurricane Center.

“Talk to your neighbors,” Berg said. “A lot of people in Florida have experienced these storms and they can help you through a storm if you’ve never been through one before.”
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GENEVA — As Brazil’s heavily flooded southern state of Rio Grande do Sul braces for a weekend of intense rain, the U.N. refugee agency, UNHCR, is calling for greater support to help tens of thousands of refugees, who are among the most vulnerable people affected by the disaster.

“Those affected include some 41,000 refugees and others in need of international protection, including many Venezuelans and Haitians who live in the affected areas — some of [whom] can only be reached by boat,” William Spindler, UNHCR spokesperson, told journalists Friday in Geneva.

According to local authorities, at least 126 people have died in the floods, 141 are missing, about 2 million people are adversely affected, and more than 400,000 are homeless.

Spindler said the UNHCR, in coordination with local authorities, is distributing relief items such as blankets and mattresses, noting that additional relief items such as emergency shelters, kitchen sets, solar lamps and hygiene kits are being sent to Brazil.

“In the coming days, UNHCR will be supporting the issuance of documentation, where it has been lost or damaged, to guarantee refugees and asylum-seekers continue to access social benefits and public services,” he said.

Spindler noted that refugees do not live in camps separated from the population, but that they live with the host communities, under the same conditions in which the local inhabitants live.

“So, it is the host communities that is the focus of our support. … We need to strengthen their capacity, so they can continue to host refugees. That means strengthening social services, access to education, to health, and so on for the local people, as well as the refugees,” he said.

The UNHCR estimates $3.21 million is needed to support the most urgent needs, including direct financial assistance to flood-affected people and the provision of essential relief items.

Brazil is a country prone to natural disasters. It has been subject to more frequent and devastating extreme weather events in recent years, including droughts in the Amazon region and severe rains in Bahia and Acre states.

A report issued this week by the World Meteorological Organization on the state of the climate in Latin America and the Caribbean highlights the vulnerability of the entire region to extreme weather and climate change impacts in 2023.

The authors of the report say it is difficult to know whether conditions this year will be worse. But WMO spokesperson Clare Nullis observes that for those affected by the disastrous floods in Brazil, “2024 is an absolutely record-breaking bad year.”

She emphasized that the flooded area is huge. “It is massive, and it really will undermine the socio-economic development in that entire area for a long time to come.”

She said El Nino, a weather phenomenon that warms ocean surface temperatures in the eastern Pacific Ocean, is playing a major role in the floods in Brazil, as it also is in the floods in Eastern Africa.

“On top of that, you have got climate change. … It is a double whammy of El Nino and climate change. And that is what we are seeing in Brazil right now. Even when El Nino fades, which it will do, the long-term effects of climate change are with us,” she said.

“Our weather is on steroids,” Nullis said, adding that every fraction of a degree of global warming means “our weather will become more extreme.”

The UNHCR’s Spindler noted severe climate events disproportionately affect refugees and other people requesting international protection. Therefore, he said it is important to work on prevention and to focus on populations that are most at risk.

“The impact of climate change affects everybody, but some individuals and communities are in a more vulnerable situation,” he said, noting that refugees and migrants are most imperiled because they are not from the country in which they are living.

“They come from other countries, and that means they do not have the same social networks, family and so on that nationals have.

“Often, they are living in areas that are more exposed to risks. So, they are impacted in a more disproportionate way by these events,” he said, underscoring that not enough funding is available to address the impact of climate change nor “to address the needs of those forcibly displaced, nor the communities hosting them.”

“Without help to prepare for, withstand and recover from climate-related shocks, they face an increased risk of further displacement,” he warned.
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ISLAMABAD — The United Nations and Taliban authorities said Saturday that the death toll from flash floods following heavy seasonal rains in Afghanistan’s northern Baghlan province had risen to a least 300.

The U.N. World Food Program said the flooding destroyed more than 1,000 houses. It said that “this has been one of many floods over the last few weeks due to unusually heavy rainfall.”

A senior Taliban official said in a social media video message that Friday’s calamity had left at least 150 people dead in a single Baghlan district called Nahreen.

Ghulam Rasool Qani said the death toll might rise and noted that military helicopters had arrived in the area to assist in local rescue efforts.

Authorities said that rescue workers are bringing aid to hardest-hit Baghlan districts. The WFP said it was distributing fortified biscuits to the survivors.

Zabihullah Mujahid, the Taliban government spokesperson, stated on social media platform X that the flooding had caused devastation in several other northern and western provinces, including Badakhshan, Ghor and Herat.

“Regrettably, hundreds of our fellow citizens have succumbed to these calamitous floods, while a substantial number have sustained injuries,” Mujahid wrote. “Moreover, the deluge has wrought extensive devastation upon residential properties, resulting in significant financial losses.”

Mujahid said the government had directed the Ministry of Disaster Management and other relevant authorities “to mobilize all available resources expeditiously” to rescue victims and bring them to safer areas, evacuate bodies, and provide timely medical treatment to those injured.

“We also urge our fellow citizens to assist the affected victims of this natural disaster to the best of their abilities and collaborate with the flood-stricken individuals,” Mujahid said.

Poverty-stricken Afghanistan also experienced heavy rains and flash floods across 32 of its 34 provinces in mid-April, resulting in the deaths of more than 100 people.

According to international aid groups, the flooding destroyed nearly 1,000 homes and about 24,000 hectares (59,800 acres) of agricultural land, along with critical infrastructure, such as roads and bridges, and electricity supplies, which could hinder the delivery of humanitarian assistance.

Richard Bennett, the U.N. special rapporteur on the Afghan human rights situation, expressed his condolences to the victims’ families.

“Recent floods in Afghanistan, including Baghlan, which claimed many lives, are a stark reminder of Afghanistan’s vulnerability to the climate crisis & both immediate aid and long-term planning by the Taliban & internal actors are needed,” Bennett wrote Saturday on X.

An estimated 80% of the more than 40 million people in Afghanistan depend on agriculture to survive. The war-ravaged South Asian nation is ranked sixth among the countries most vulnerable to climate change, which experts say is responsible for the unusually heavy seasonal rains.

Aid workers had warned before Friday’s devastation that any additional flooding would be detrimental for large swathes of the Afghan population, already reeling from an economic collapse, high levels of malnutrition and conflict.

“Three years of successive drought and the harshest winter in 15 years have exacerbated Afghanistan’s hunger crisis at a time when international support is falling,” the U.S.-based International Rescue Committee, or IRC, said in its latest assessment, published last week.

The report said that an estimated 15.3 million Afghans, or 35% of the population, continue to suffer from crisis or worse levels of food insecurity. “Nearly half of the population lives in poverty and will continue to experience economic hardship,” the IRC said.

Afghanistan’s economy crashed after the Taliban militarily seized power in 2021 as the then-internationally supported government collapsed and U.S.-led international forces withdrew after 20 years of involvement in the Afghan war.

The Taliban takeover led to the termination of foreign development funding for Afghanistan, and its banking system largely remains isolated over terrorism-related concerns, as well as sanctions on Taliban leaders.
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